Gastroenterology

CPT 45380 vs 45385

Colonoscopy with Biopsy vs Colonoscopy with Polypectomy — side-by-side RVU comparison with clinical guidance on when to use each code.

Key Difference

Polypectomy (45385) carries higher RVUs than biopsy alone (45380) due to the greater complexity and risk of polyp removal.

Clinical Documentation Tip

Snare polypectomy should be distinguished from hot biopsy forceps removal. Each technique has specific coding requirements.

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